Premium
High amyloid‐β deposition related to depressive symptoms in older individuals with normal cognition: a pilot study
Author(s) -
Yasuno Fumihiko,
Kazui Hiroaki,
Morita Naomi,
Kajimoto Katsufumi,
Ihara Masafumi,
Taguchi Akihiko,
Yamamoto Akihide,
Matsuoka Kiwamu,
Kosaka Jun,
Kudo Takashi,
Iida Hidehiro,
Kishimoto Toshifumi,
Nagatsuka Kazuyuki
Publication year - 2016
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4409
Subject(s) - pittsburgh compound b , precuneus , geriatric depression scale , medicine , alzheimer's disease , psychology , posterior cingulate , depressive symptoms , cognition , psychiatry , disease
Objective Previous studies have reported depressive symptoms in the preclinical stages of Alzheimer's disease (AD). The objective of this study was to determine whether depressive symptoms are associated with cortical amyloid burden. In order to do this, we measured cortical amyloid via 11 C‐labeled Pittsburgh Compound B ([ 11 C]PIB) uptake using positron emission tomography (PET) in cognitively normal subjects. Methods We performed [ 11 C]PIB‐PET in 29 cognitively normal, older participants. Depressive symptoms were assessed using the 15‐item Geriatric Depression Scale (GDS). Aβ deposition was quantified by binding potential (BP ND ), and the association between cortical mean BP ND values and GDS scores was evaluated. Analysis of parametric BP ND images was performed to examine the relationship between regional BP ND and GDS scores. Results We found a positive correlation between depressive symptoms and mean cortical PIB‐BP ND in groups of subjects with middle to high PIB‐BP ND . There was little change in GDS‐depression score between subjects with low and middle PIB‐BP ND levels, while an increase in GDS was shown in the high PIB‐BP ND group. The main BP ND increase was localized to the precuneus/posterior cingulate cortex (PCu/PCC) in subjects with high PIB‐BP ND , and we found a significant positive relationship between PIB‐BP ND in this area and depressive symptoms. Conclusions Emotional dysregulation because of Aβ neuropathology in the PCu/PCC may relate to depressive symptoms. More specifically, we found that older, cognitively normal patients with depressive episodes were more likely to have underlying AD pathology. Thus, depressive symptoms may increase the predictive ability of the identification of future AD cases. Copyright © 2016 John Wiley & Sons, Ltd.