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Gray matter atrophy in patients with mild cognitive impairment/Alzheimer's disease over the course of developing delusions
Author(s) -
Fischer Corinne E.,
Ting Windsor KwanChun,
Millikin Colleen P.,
Ismail Zahinoor,
Schweizer Tom A.
Publication year - 2016
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4291
Subject(s) - precuneus , parahippocampal gyrus , neuroimaging , psychology , voxel based morphometry , lingual gyrus , grey matter , atrophy , dementia with lewy bodies , alzheimer's disease , dementia , posterior cingulate , insula , neuroscience , audiology , cognition , medicine , disease , temporal lobe , white matter , magnetic resonance imaging , pathology , radiology , epilepsy
Objective We conducted a neuroimaging analysis to understand the neuroanatomical correlates of gray matter loss in a group of mild cognitive impairment and early Alzheimer's disease patients who developed delusions. Methods With data collected as part of the Alzheimer's Disease Neuroimaging Initiative, we conducted voxel‐based morphometry to determine areas of gray matter change in the same Alzheimer's Disease Neuroimaging Initiative participants, before and after they developed delusions. Results We identified 14 voxel clusters with significant gray matter decrease in patient scans post‐delusional onset, correcting for multiple comparisons (false discovery rate, p < 0.05). Major areas of difference included the right and left insulae, left precuneus, the right and left cerebellar culmen, the left superior temporal gyrus, the right posterior cingulate, the right thalamus, and the left parahippocampal gyrus. Conclusions Although contrary to our initial predictions of enhanced right frontal atrophy, our preliminary work identifies several neuroanatomical areas, including the cerebellum and left posterior hemisphere, which may be involved in delusional development in these patients. Copyright © 2015 John Wiley & Sons, Ltd.