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The relationship between cognitive performance and insulin resistance in non‐diabetic patients with mild cognitive impairment
Author(s) -
Kim TaeEun,
Lee Dong Hyun,
Kim YoonJeong,
Mok Ji Oh,
Kim Chul Hee,
Park JeongHo,
Lee TaeKyeong,
Yoo Kwangsun,
Jeong Yong,
Lee Yunhwan,
Park Sun Ah
Publication year - 2015
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4181
Subject(s) - insulin resistance , cognition , medicine , apolipoprotein e , diabetes mellitus , insulin , psychology , endocrinology , psychiatry , disease
Objective Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. IR is thought to play a vital role in cognitive impairment. We conducted this study to understand the early characteristics of cognitive dysfunctions attributable to IR. Methods This study included 85 consecutive non‐diabetic elderly participants with mild cognitive impairment (MCI). IR was estimated with the homeostasis model assessment of insulin resistance (HOMA‐IR). Cognitive performances were analyzed as a function of scores on the HOMA‐IR. Results The group analysis those with and without IR did not show any differences in the cognitive performance although higher HOMA‐IR was closely associated with lower performances in immediate recall on the Seoul Verbal Learning Test (SVLT‐I) ( r = −0.244, p = 0.026) and Controlled Oral Word Association Test (COWAT) ( r = −0.270, p = 0.013). In subgroup analysis by APOE status, SVLT‐delayed ( p = 0.027) and COWAT ( p = 0.016) scores were found to be significantly lower in the IR than the non‐IR among those with APOE ε4 allele. In multiple regression analysis, impairment on the COWAT remained significantly correlated with scores on HOMA‐IR ( β = −0.271, t = −2.340, p = 0.022). However, IR status was identified to interact with APOE ε4 carriership toward poor performances in the COWAT ( β = −0.335, t = −2.285, p = 0.026). Conclusion This study found a domain‐specific impact of HOMA‐IR scores on cognitive performances in non‐diabetic patients with MCI. This association was profound only in APOE ε4carriers. Copyright © 2014 John Wiley & Sons, Ltd.