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Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study
Author(s) -
MukaetovaLadinska Elizabeta B.,
AbdelAll Zeinab,
Andrade Joana,
Alves da Silva Joaquim,
O'Brien John T.,
Kalaria Raj N.
Publication year - 2015
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4145
Subject(s) - clusterin , dementia , apathy , psychology , disease , platelet , alzheimer's disease , cognition , depression (economics) , medicine , irritability , psychiatry , clinical psychology , apoptosis , biochemistry , chemistry , economics , macroeconomics
Background Clusterin protein in plasma has been found to differentiate between people with and without cognitive changes. However, these findings are not conclusive, despite the clusterin gene variations repeatedly being linked to increased risk for dementia, in particular Alzheimer's disease (AD). Method We analysed the level of clusterin in platelet and plasma in 25 subjects with a clinical diagnosis of AD and 26 subjects with no cognitive impairment. Results In the current study, we report that the levels of both plasma and platelet clusterin are similar between AD and cognitively intact individuals. Clusterin plasma and platelet levels, as well as the plasma/platelet clusterin ratio, were not affected by age, gender, cognitive impairment and/or overt behavioural symptomatology, including presence of hallucinations and delusions, as well as depression. However, the plasma/platelet clusterin ratio was positively associated in with the Neuropsychiatric Inventory measures of agitation, apathy, irritability and motor aberrant behaviour in AD subjects. Conclusion Previous inconsistencies in reported blood clusterin levels may be a result of underlying non‐cognitive symptoms in people with AD. Our findings need now to be replicated in larger group of dementia subjects. Copyright © 2014 John Wiley & Sons, Ltd.