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The efficacy of plasma biomarkers in early diagnosis of Alzheimer's disease
Author(s) -
Wang Tao,
Xiao Shifu,
Liu Yuanyuan,
Lin Zhiguang,
Su Ning,
Li Xia,
Li Guanjun,
Zhang Mingyuan,
Fang Yiru
Publication year - 2014
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.4053
Subject(s) - biomarker , pathological , medicine , disease , oncology , amnesia , cognitive impairment , analysis of variance , alzheimer's disease , degenerative disease , gastroenterology , psychology , pathology , psychiatry , biology , biochemistry
Background Early diagnosis of Alzheimer's disease (AD) is imperative for the prevention of disease progression and the development of effective treatments. Objective Clinically, AD diagnosis has been based on adherence to clinical criteria. It has recently been proposed that diagnostic criteria should also incorporate biomarker findings. However, the most studied candidates or group of candidates for AD biomarkers, including pathological processes and proteins, needs further research. The current study aimed to investigate the capabilities of the following plasma proteins in the diagnosis of AD and amnesia mild cognitive impairment (aMCI): peripheral interleukin (IL) 10, IL‐6, amyloid‐β (Aβ) 40, Aβ42, phosphorylated tau 181, and total tau. Methods In addition to 122 normal control (NC) group, 97 AD patients and 54 aMCI patients were recruited for this study. An enzyme‐linked immunosorbent assay was used to analyze the concentration of the following blood plasma biomarkers: IL‐10, IL‐6, Aβ40, Aβ42, phosphorylated tau 181, and total tau. Results A one‐way analysis of variance (one‐factor analysis of variance) of Aβ40 and IL‐10 levels revealed a statistically significant difference between the three groups ( p < 0.001 and p = 0.020). Using Aβ40 ≥ 42.70 pg/ml as the cut‐off point, the sensitivity of the ability of Aβ40 to discriminate between AD and NC groups was 80.0%, and specificity was 69.6%. Conclusions The plasma Aβ40 biomarker was able to distinguish between AD and NC groups. However, the plasma biomarkers in the present research were not able to distinguish between aMCI and NC groups. Copyright © 2013 John Wiley & Sons, Ltd.