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Subclinical hypothyroidism, mood, and cognition in older adults: a review
Author(s) -
Joffe Russell T.,
Pearce Elizabeth N.,
Hennessey James V.,
Ryan Joseph J.,
Stern Robert A.
Publication year - 2013
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.3796
Subject(s) - subclinical infection , mood , cognition , medicine , psychology , clinical psychology , association (psychology) , hormone replacement therapy (female to male) , cognitive decline , psychiatry , dementia , psychotherapist , disease , testosterone (patch)
Objectives To perform a critical review of the literature on the mood and cognitive changes associated with subclinical hypothyroidism (SCH), with an emphasis on older adults. To evaluate these data against the Consensus Statement on the management of SCH from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society. Method A comprehensive literature review. Results Subclinical hypothyroidism may be associated with an increased risk of mood and cognitive dysfunction, although the strength of this association and the efficacy of replacement hormone therapy require further investigation. Conclusion It remains unclear whether SCH leads to significant mood and cognitive impairments in most older patients. More research is required to determine the nature and extent of this association and whether thyroid hormone replacement therapy is appropriate and effective in treating SCH‐associated neurobehavioral impairments. Copyright © 2012 John Wiley & Sons, Ltd.