Premium
Depression subtypes and 5‐years risk of mortality in aged 70 years: a population‐based cohort study
Author(s) -
VilaltaFranch Joan,
PlanasPujol Xènia,
LópezPousa Secundino,
LlinàsReglà Jordi,
MerinoAguado Javier,
GarreOlmo Josep
Publication year - 2012
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.2691
Subject(s) - dementia , depression (economics) , cohort , medicine , population , cohort study , comorbidity , proportional hazards model , psychiatry , late life depression , psychology , cognition , disease , environmental health , economics , macroeconomics
Aims To estimate the mortality risk related to different mood disorders in a geriatric sample of subjects aged 70 years and over without dementia. Method All non‐demented subjects at baseline who participate on a second phase of a population‐based cohort study were included. Adjusted Cox proportional hazards models were used to determine the association between depression and 5‐year survival of 451 elderly people without dementia originally recruited for a representative community dementia cohort study. Baseline evaluation included the Cambridge Mental Disorders of the Elderly Examination Schedule. Depressive disorders (major and minor episode) were assessed according DSM‐IV criteria and classified according the age of onset (late vs. early). The late‐onset depression was classified according to the presence or absence of depression‐executive dysfunction syndrome (DEDS). Results The initial cohort size was 451 subjects, among which 10.9% ( n = 49) suffered a major depressive episode and 10.4% ( n = 47) a minor depressive disorder. Among the total affective disorders, 77.9% ( n = 74) were late‐onset depressions and 29.5% ( n = 28) had executive dysfunction. After 5 years, the vital status of 94% ( n = 424) of the participants was known and the mortality was 18.9% ( n = 80). Late‐onset major depressive episode with executive dysfunction was related to mortality after adjustment by age, gender, marital status, level of education, comorbidity (or health global status) and cognitive impairment (HR = 3.70; 95% CI = 1.55–8.83). The executive dysfunction was found to be an independent mortality risk factor (HR = 2.05; 95% CI = 1.15–3.64). Conclusions There is a statistically significant association between mortality and late‐onset major depression with executive dysfunction. Copyright © 2011 John Wiley & Sons, Ltd.