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Effects of aging on 5‐HT 2A R binding: a HRRT PET study with and without partial volume corrections
Author(s) -
Uchida Hiroyuki,
Chow Tiffany W.,
Mamo David C.,
Kapur Shitij,
Mulsant Benoit H.,
Houle Sylvain,
Pollock Bruce G.,
GraffGuerrero Ariel
Publication year - 2011
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.2682
Subject(s) - putamen , partial volume , positron emission tomography , binding potential , nuclear medicine , atrophy , radioligand , medicine , psychology , receptor
Objective We explored whether prior findings of reduction in serotonin 2A receptor (5‐HT 2A R) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age‐related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. Methods We derived 5‐HT 2A R nondisplaceable binding potentials (BP ND ) in frontal, temporal, anterior‐cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19–78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. Results The 5‐HT 2A R BP ND s decreased with age, a relationship best described by an exponential‐decay regression. The BP ND s were found to be consistent before and after PVC, with an intra‐class correlation coefficient of 0.84 and 95% confidence interval = 0.78–0.88. Conclusions These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects. Copyright © 2011 John Wiley & Sons, Ltd.