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The interaction between cerebrovascular disease and neuroticism in late‐life depression: a cross‐sectional study
Author(s) -
Wouts L.,
Janzing J.G.,
Lampe I.K.,
Franke B.,
de Vegt F.,
Tendolkar I.,
van Iersel M.B.,
Buitelaar J.K.,
Oude Voshaar R.C.
Publication year - 2011
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.2584
Subject(s) - neuroticism , depression (economics) , apathy , medicine , logistic regression , stroke (engine) , disease , population , vascular disease , cross sectional study , psychology , personality , pathology , social psychology , mechanical engineering , environmental health , engineering , economics , macroeconomics
Objective Vascular disease and neuroticism are both risk factors for late‐life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late‐life. Methods Multivariate logistic regression in a survey of 1396 population‐dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES‐D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke. Results Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4–1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6–0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6–0.96) when predicting CRDS. Conclusions In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease. Copyright © 2010 John Wiley & Sons, Ltd.