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APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study
Author(s) -
DelanoWood Lisa,
Houston Wes S.,
Emond Jennifer A.,
Marchant Natalie L.,
Salmon David P.,
Jeste Dilip V.,
Thal Leon J.,
Bondi Mark W.
Publication year - 2008
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1953
Subject(s) - apolipoprotein e , genotype , depression (economics) , allele , mood , disease , medicine , psychology , retrospective cohort study , psychiatry , alzheimer's disease , mood disorders , oncology , endocrinology , genetics , biology , anxiety , gene , macroeconomics , economics
Objective The association between the APOE ε 4 allele and depression was investigated in a retrospective study of 323 AD patients. Methods Patients were divided into demographically comparable groups based on the presence or absence of depression. Results Results showed that the frequency of APOE ε 4 allele was significantly higher in the depressed vs non‐depressed AD patients (72% and 58%, respectively), and an interaction revealed that women possessing the APOE ε 4 allele were almost four times more likely to be depressed than those without the ε 4 allele. Conclusion Results are consistent with recent suggestions that the APOE ε 4 genotype may be over‐represented among depressed women with AD and highlight the need for additional research investigating the links between APOE genotype, mood, and gender. Copyright © 2007 John Wiley & Sons, Ltd.
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