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The association of neuroleptic sensitivity in Lewy body disease with a false positive clinical diagnosis of Creutzfeldt‐Jakob disease
Author(s) -
Lemstra A.W.,
Schoenmaker N.,
RozemullerKwakkel A.J.M.,
van Gool W.A.
Publication year - 2006
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1602
Subject(s) - dementia with lewy bodies , dementia , lewy body , medicine , disease , confusion , autopsy , psychiatry , pediatrics , psychology , pathology , psychoanalysis
Background Dementia with Lewy bodies (DLB) and Creutzfeldt‐Jakob disease (CJD) share clinical features like cognitive decline, motor disturbances en psychiatric symptoms. Overlapping symptoms may cause physicians to mistake DLB for CJD. Methods Clinical data of 12 patients with autopsy‐confirmed DLB who had been clinically suspected to suffer from CJD were analysed to investigate possible clinical features which led to misdiagnosis. Results There was an association in time between administering neuroleptics and rapid clinical deterioration in 8 out of 9 patients. Conclusion It is suggested that the neuroleptic sensitivity in LBD fuelled the misdiagnosis of CJD in the presented series. Diagnostic confusion between CJD and DLB may have important clinical consequences and may lead to treatment restrictions. Copyright © 2006 John Wiley & Sons, Ltd.