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Elevation of plasma concentration of adhesion molecules in late‐life depression
Author(s) -
Dimopoulos Nikolaos,
Piperi Christina,
Salonicioti Aristea,
Mitsonis Charalampos,
Liappas Ioannis,
Lea Robert W.,
Kalofoutis Anastasios
Publication year - 2006
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1592
Subject(s) - depression (economics) , elevation (ballistics) , late life depression , adhesion , medicine , psychology , chemistry , physics , hippocampal formation , economics , macroeconomics , organic chemistry , astronomy
Objectives Late‐life depression may be associated with vascular disease. The purpose of the study was to investigate this association by determining the levels of soluble adhesion molecules (sICAM‐1 and sVCAM‐1) which represent markers of ischemia‐induced inflammation in elderly individuals with depression. Methods Blood samples were obtained from 33 subjects with depression selected from a community‐dwelling population after screening with the Geriatric Depression Scale, and 33 matched controls. Serum concentrations of sICAM‐1 (ng/mL) and sVCAM‐1 (ng/mL) were measured in both groups. Results Depressed patients (Group A) possessed significantly higher sICAM‐1 levels compared to healthy controls (Group B) (674.94 ± 166.90 ng/ml vs 467.05 ± 231.26 ng/ml, respectively, p < 0.01). Similarly the same groups demonstrated elevated sVCAM‐1 levels compared to controls (572.14 ± 182.20 ng/ml vs 449.04 ± 285.27 ng/ml, p < 0.05); a difference that in both cases remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Conclusion These findings indicate an association between high serum levels of VCAM‐1, and ICAM‐1 and depression in the elderly and further support the vascular depression hypothesis, which has important implications for the understanding and management of late‐life depression. Copyright © 2006 John Wiley & Sons, Ltd.