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Decreased plasma antioxidants in patients with Alzheimer's disease
Author(s) -
Kim TaeSuk,
Pae ChiUn,
Yoon SuJung,
Jang WooYoung,
Lee Nam Jin,
Kim JungJin,
Lee SooJung,
Lee Chul,
Paik InHo,
Lee ChangUk
Publication year - 2006
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1469
Subject(s) - uric acid , bilirubin , albumin , medicine , pathogenesis , alzheimer's disease , antioxidant , confounding , disease , oxidative stress , gastroenterology , cognition , body mass index , endocrinology , serum albumin , biochemistry , chemistry , psychiatry
Objectives It has been suggested that oxidative injuries have an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we assess whether the plasma levels of albumin, bilirubin, and uric acid would be altered in the AD patients compared to those of the healthy controls. Furthermore, we tried to find the correlations between plasma antioxidant levels and the cognitive function in AD patients. Methods The plasma albumin, bilirubin, and uric acid levels were measured by standard methods in 101 AD patients and 101 healthy controls. The Korean version of the Mini Mental Status Examination (MMSE‐K) was used to evaluate the cognitive functions of AD patients. Results A significant reduction in the albumin, bilirubin, and uric acid levels in the AD group was found compared to those of the control group. The scores of MMSE‐K showed the positive correlation with albumin level in the AD group after adjusting confounding factors such as body mass index, gender and age. Conclusion This study showed that oxidative injuries could be involved in the pathogenesis of AD, as well as indicating that some antioxidant might be associated with the cognitive functions in AD. Copyright © 2006 John Wiley & Sons, Ltd.