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Cognitive correlates of brain MRI subcortical signal hyperintensities in non‐demented elderly
Author(s) -
Marshall Gad A.,
Hendrickson Rick,
Kaufer Daniel I.,
Ivanco Larry S.,
Bohnen Nicolaas I.
Publication year - 2006
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1419
Subject(s) - stroop effect , hyperintensity , cognition , psychology , memory span , audiology , effects of sleep deprivation on cognitive performance , cognitive test , magnetic resonance imaging , rating scale , working memory , medicine , psychiatry , developmental psychology , radiology
Objective To investigate the relationship between magnetic resonance imaging (MRI) subcortical gray and capsular (SGCH) and white matter hyperintensities (WMH) and cognitive functions in non‐demented community dwelling elderly. Methods The severity of SGCH and WMH on proton density and T2 MR images in 16 subjects was scored using the semi‐quantitative rating scale of Scheltens et al . (1993). A limited series of cognitive tests selected a priori were then correlated with severity of SGCH and WMH. Results Analysis demonstrated that severity of SGCH was inversely related to performance on the Digit Span ( R = −0.64, p < 0.01) and the Stroop Color Word Tests ( R = −0.64, p < 0.01). Severity of WMH was related to worsening performance on the Trail Making Test ( R = 0.67, p < 0.005). Conclusions These findings indicate that severity of WMH is negatively related to more pure executive cognitive functions, specifically set shifting, while severity of SGCH is inversely related to more basic functions of attention and working memory. Copyright © 2005 John Wiley & Sons, Ltd.