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Somatic symptoms of depression in elderly patients with medical comorbidities
Author(s) -
Drayer Rebecca A.,
Mulsant Benoit H.,
Lenze Eric J.,
Rollman Bruce L.,
Dew Mary Amanda,
Kelleher Kelly,
Karp Jordan F.,
Begley Amy,
Schulberg Herbert C.,
Reynolds Charles F.
Publication year - 2005
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1389
Subject(s) - depression (economics) , psychiatry , comorbidity , medicine , gerontology , somatic cell , economics , macroeconomics , biochemistry , chemistry , gene
Objective Somatic symptoms of depression such as fatigue create a diagnostic dilemma when assessing an older patient with medical comorbidities, since chronic medical illnesses may produce similar symptoms. Alternatively, somatic symptoms attributed to medical illness may actually be caused by depression. These analyses were designed to determine if somatic symptoms in older patients are more strongly associated with chronic physical problems or with depression. Design Reanalysis of data from an observational study of depression in primary care and a randomized trial of paroxetine and nortriptyline for the treatment of major depression. Patients were evaluated with a structured diagnostic interview and a battery of psychiatric, physical, and psychosocial measures. Participants Two hundred and forty eight primary care and psychiatric patients aged ≥ 60 years. Methods Associations among depression, somatization, and chronic physical problems were examined using correlations and regression modeling. Results Two somatization measures, the Asberg Side Effects Rating Scale and the Utvalg for Kliniske Undersogelser (UKU), were significantly associated with psychological symptoms of depression ( r = 0.73 and r = 0.76, p < 0.0001) but not with medical comorbidities ( r = 0.02, p = 0.16 and r = 0.10, p = 0.78). In multiple regression models, psychological symptoms of depression remained significant predictors of somatization ( p < 0.0001) after controlling for age, gender, and medical comorbidities. Conclusions In older patients with medical disorders and multiple somatic complaints, clinicians should consider the possibility of depression. Rating scales emphasizing somatic symptoms associated with depression may provide a more accurate measure of depression severity than those excluding such symptoms. Copyright © 2005 John Wiley & Sons, Ltd.