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The heterogeneity of frontotemporal dementia with regard to initial symptoms, qEEG and neuropathology
Author(s) -
Passant Ulla,
Rosén Ingmar,
Gustafson Lars,
Englund Elisabet
Publication year - 2005
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1388
Subject(s) - neuropathology , frontotemporal dementia , psychology , electroencephalography , dementia , white matter , age of onset , pathology , audiology , pediatrics , medicine , neuroscience , psychiatry , magnetic resonance imaging , disease , radiology
Objectives/Methods Ten patients with neuropathologically verified frontotemporal dementia (FTD) were analysed for neuropathological features in relation to first presenting and dominating symptoms, age at onset and duration of dementia, as well as to EEG/quantitative EEG. Results Cases with a late onset (> 65 years) initially presented language disturbances, while the early onset group (< 65 years) showed predominantly behavioural symptoms and mood alterations as early features. The late onset group presented combined cortical‐subcortical degeneration including white matter pathology, while early onset cases showed pathology predominantly in the cortex. EEG was normal in the late onset group, while it was mildly and variably abnormal in those with early onset. Conclusions Within this small sample of clinical and neuropathological FTD, cases with late vs early onset differed with respect to initial symptoms, EEG findings and regional distribution of brain pathology. Copyright © 2005 John Wiley & Sons, Ltd.