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White matter hyperintensities and depression—preliminary results from the LADIS study
Author(s) -
Firbank Michael J.,
O'Brien John T.,
Pakrasi Sanjeet,
Pantoni Leonardo,
Simoni Michela,
Erkinjuntti Timo,
Wallin Anders,
Wahlund LarsOlof,
Straaten Ilse van,
Inzitari Domenico
Publication year - 2005
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1342
Subject(s) - hyperintensity , depression (economics) , geriatric depression scale , logistic regression , psychology , rating scale , quality of life (healthcare) , ordered logit , medicine , depressive symptoms , psychiatry , magnetic resonance imaging , cognition , developmental psychology , radiology , machine learning , computer science , economics , psychotherapist , macroeconomics
Background White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood. Methods In a pan‐European multicentre study of 629 older subjects, we examined the relationship between MRI white matter hyperintensities (WMH), depressive symptoms and self perceived health quality of life (QOL). WMH were rated using a three‐point scale. Results We found depressive symptoms as assessed by the geriatric depression 15‐item scale to be associated with WMH rating (Spearman's rho 0.11, p = 0.008) and also with the Euro‐QOL health score (Spearman's rho −0.5, p < 0.001). In a ordinal logistic regression model, QOL was found to strongly predict GDS score ( p < 0.001) and severe vs mild WMH were associated with increased depression ( p = 0.028). The relationship between history of severe depression and WMH score was examined, but there were no differences either between those with and without a history of severe depression, or those with an early vs late onset of depression. Conclusions The results suggest that WMH play a role in increasing depressive symptoms, even when perceived quality of life is controlled for as a possible mediating factor. Copyright © 2005 John Wiley & Sons, Ltd.