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Clinical application of operationalized criteria for ‘Depression of Alzheimer's Disease’
Author(s) -
Rosenberg Paul B.,
Onyike Chiadi U.,
Katz Ira R.,
Porsteinsson Anton P.,
Mintzer Jacobo E.,
Schneider Lon S.,
Rabins Peter V.,
Meinert Curtis L.,
Martin Barbara K.,
Lyketsos Constantine G.
Publication year - 2005
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1261
Subject(s) - operationalization , depression (economics) , disease , psychology , depressive symptoms , medical diagnosis , psychiatry , alzheimer's disease , clinical psychology , medicine , cognition , pathology , philosophy , epistemology , economics , macroeconomics
Objectives ‘Depression of Alzheimer's Disease’ (dAD) is a common complication of Alzheimer's disease and is increasingly recognized as a syndrome with a clinical presentation differing from major depression. Criteria for the diagnosis of dAD have been proposed previously. Methods This paper presents these criteria in operationalized format designed to be accessible for clinical use. Four cases are discussed that demonstrate the use of these criteria and illustrate important differences between dAD and major depression. Results The dAD criteria are broader than DSM‐IV criteria for Major Depressive Episode and incorporate caregiver input. Conclusions Given the differences between dAD and major depression diagnoses, it is important to assess the efficacy of treatments for dAD. Depression in Alzheimer's Disease‐2 (DIADS‐2) is a controlled trial of dAD treatments that will also assess the validity of these criteria. Copyright © 2005 John Wiley & Sons, Ltd.