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5‐HT 2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease
Author(s) -
Lam Linda Chiu Wa,
Tang Nelson Leung Sang,
Ma Suk Ling,
Zhang Weimin,
Chiu Helen Fung Kum
Publication year - 2004
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1109
Subject(s) - apathy , delusion , genotype , medicine , disease , alzheimer's disease , polymorphism (computer science) , receptor , psychology , psychiatry , genetics , gene , biology
Objective To investigate the association between 5‐HT 2A receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD). Methods This case‐control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty‐seven subjects with NINCDS‐ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5‐HT 2A receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI). Results The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05). Conclusions Specific NP symptoms in AD were significantly associated with 5‐HT 2A receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5‐HT 2A receptor polymorphisms are worthy of further exploration. Copyright © 2004 John Wiley & Sons, Ltd.