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A longitudinal study of neuropsychological change in individuals with Parkinson's disease
Author(s) -
Azuma Tamiko,
Cruz Robyn F.,
Bayles Kathryn A.,
Tomoeda Cheryl K.,
Montgomery Erwin B.
Publication year - 2003
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/gps.1015
Subject(s) - neuropsychology , wisconsin card sorting test , psychology , neuropsychological test , verbal fluency test , trail making test , cognitive decline , cognition , audiology , clinical psychology , psychiatry , disease , medicine , dementia
Neuropsychological changes in individuals with Parkinson's disease (PD) were studied longitudinally. Sixty‐nine idiopathic PD patients, with Mini‐Mental State Examination (MMSE) scores falling within normal range, and 37 elderly control participants were given neuropsychological tests twice approximately two years apart. The PD group performed poorer than the control group on Semantic Fluency, Letter Fluency, Modified Wisconsin Card Sorting Task, and Block Design at test time 1. Two years later, the PD group showed significant decline in Semantic and Letter Fluency. A subset of 12 PD patients declined in mental status by second testing (≥4 MMSE points). Cox proportional‐hazards models were used to see if any baseline measures were associated with relative risk of decline in mental status. In the final model, Repetition performance and Age were significantly associated with cognitive decline. Consistent with previous studies, executive function tasks were those most susceptible to disease progression. Copyright © 2003 John Wiley & Sons, Ltd.