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Expression of BMP‐6, a TGF‐β related morphogenetic cytokine, in rat radial glial cells
Author(s) -
Schluesener Hermann J.,
Meyermann Richard
Publication year - 1994
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440120210
Subject(s) - biology , bone morphogenetic protein , cytokine , bone morphogenetic protein 2 , microbiology and biotechnology , transforming growth factor , neuroscience , immunology , genetics , gene , in vitro
Bone morphogenetic protein‐6 (BMP‐6) is a member of the TGF‐β super‐family of cytokines. The bone morphogenetic proteins and homologous cytokines participate in realization of the genetic body plan by regulating homeotic gene expression, embryonic development, and neurogenesis. Here we demonstrate expression of BMP‐6 in rat radial glial cells which are involved in embryonic organisation of the central nervous system. Thus, morphogenetic cytokines like BMP‐6 might contribute to radial glial cell function in organizing the migration of immature neurons during the development of the CNS cortex.