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Maturation of the GFAP‐immunopositive glial network is delayed in the olfactory bulbs of rats subjected to early, low‐dose X‐irradiation
Author(s) -
Hajós Ferenc,
Mészáros Melinda,
Halász Norbert
Publication year - 1994
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440120208
Subject(s) - olfactory bulb , biology , olfactory system , glial fibrillary acidic protein , neuroscience , astrocyte , central nervous system , anatomy , immunohistochemistry , immunology
Young rats were subjected to low‐level, repeated doses of x‐irradiation from a Co 60 source and examined for the presence and arrangement of their GFAP‐immunopositive system at the light and electron microscopic levels. In 2‐week‐old control rats, labelled cells were already distributed homogeneously throughout the bulb, while in the experimental animal, a (newborn‐ and early postnatal‐type) radial arrangement of immunoreactive fibres continued to persist even until the end of the fourth postnatal week. This delay in the maturation of the GFAP‐immunopositive glial system may contribute to the hindered development of the bulbar neurones, neuronal connections, and field potentials, as found in earlier studies.