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Expression and regulation of a glutamate receptor subunit by bFGF in oligodendrocyte progenitors
Author(s) -
Gallo Vittorio,
Wright Paul,
McKin Randall D.
Publication year - 1994
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440100209
Subject(s) - biology , oligodendrocyte , glutamate receptor , protein subunit , progenitor cell , neuroscience , microbiology and biotechnology , receptor , central nervous system , genetics , stem cell , myelin , gene
Oligodendrocyte progenitor cells (O‐2A) express both kainate‐preferring and AMPA‐preferring glutamate receptors (Gallo et al., Soc. Neurosci. Abstr., 18:653, 1992b; Gallo et al., 1994). The expression and regulation of the GluR‐4c, AMPA‐preferring subunit by growth factors was studied by Northern blot analysis of total RNA from purified rat cortical O‐2A progenitors. Differently from cortical neurons, O‐2A progenitors only expressed two high molecular weight GluR‐4c transcripts (6.2 and 4.2 kb), as observed also in cultured astrocytes. Basic fibroblast growth factor (bFGF) increased GluR‐4c transcript levels in O‐2A progenitors and its effects were not mimicked by platelet derived growth factor (PDGF) or fetal calf serum. Therefore, bFGF may regulate O‐2A progenitor responsiveness to glutamate during development through the expression of glutamate receptor subunits. © 1994 Wiley‐Liss, Inc.