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Diazepam binding inhibitor fragment 33–50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells
Author(s) -
Vidnyánszky Zoltán,
Görcs Tamás J.,
Hámori József
Publication year - 1994
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440100207
Subject(s) - colocalization , cerebellum , cerebellar cortex , neuroscience , biology , neuroglia , cortex (anatomy) , cerebral cortex , hippocampus , central nervous system
The distribution of octadecaneuropeptide (ODN)‐like immunoreactivity (LI) and its relationship to γ‐aminobutyric acid (GABA)‐LI were investigated in the cerebellar cortex of adult rats with electron microscopy. At the electron microscopic level, ODN‐LI was found exclusively in glial cells. In addition to Bergmann glia and its processes, cerebellar astrocytes were also labelled, encapsulating unlabelled neuronal elements of the cerebellum. These ODN‐LI glial processes were observed in close apposition to synaptic junctions, but immunoreactivity could not be found in the synaptic cleft or in association with neuronal membranes. Since GABA‐LI is always associated with neuronal elements, the colocalization of GABA‐ and ODN‐LI could not be confirmed in the cerebellar cortex. Our results do not support the assumption that ODN is a neuron‐specific processing product of diazepam binding inhibitor. © 1994 Wiley‐Liss, Inc.