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5′‐Nucleotidase immunoreactivity of perineuronal microglia responding to rat facial nerve axotomy
Author(s) -
Schoen S. W.,
Graeber M. B.,
Kreutzberg G. W.
Publication year - 1992
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440060410
Subject(s) - axotomy , microglia , biology , 5' nucleotidase , neuroscience , lesion , perineuronal net , immunocytochemistry , population , neuroglia , pathology , facial nerve , anatomy , central nervous system , adenosine , immunology , endocrinology , medicine , inflammation , environmental health
The ecto‐enzyme 5′‐nucleotidase was localized immunocytochemically in the axotomized rat facial nucleus. As revealed by the monoclonal antibody 5N4–2,5′‐nucleotidase immunoreactivity markedly increased on perineuronal microglia during the first week following axotomy, and gradually disappeared from these cells by the end of the third post‐operative week. Interestingly, parenchymal microglia were not or only weakly stained. These findings indicate that 5′‐nucleotidase 5N4‐2‐immunoreactivity may serve as a marker for perineuronal microglia, a population of satellite glial cells that appear to be actively engaged in lesion‐induced synaptic changes during regeneration. © 1992 Wiley‐Liss, Inc.