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PDGF increases the expression of fos and jun in newly formed oligodendrocytes that have become resistant to the mitogenic effect of PDGF
Author(s) -
Hart I. K.,
Richardson W. D.,
Raff M. C.
Publication year - 1992
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440060409
Subject(s) - platelet derived growth factor receptor , biology , microbiology and biotechnology , platelet derived growth factor , progenitor cell , oligodendrocyte , nucleus , growth factor , neuroglia , neuroscience , mitosis , central nervous system , myelin , stem cell , genetics , receptor
Bipotential glial (O‐2A) progenitor cells give rise to oligodendrocytes on a predictable schedule in the developing rat optic nerve. The loss of mitotic responsiveness to platelet‐derived growth factor (PDGF) that is seen when O‐2A progenitor cells initially differentiate into oligodendrocytes seems to reflect blocks or deficiencies downstream to some of the early intracellular signalling events induced by PDGF. Here we show that PDGF increases the expression of the Fos and Jun nuclear proteins in newly formed oligodendrocytes in vitro, suggesting that at least one intracellular signalling pathway to the nucleus is activated by PDGF in these cells even though they do not synthesize DNA in response to PDGF. © 1992 Wiley‐Liss, Inc.