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Platelet‐derived growth factor is mitogenic for O‐2A adult progenitor cells
Author(s) -
Wolswijk Guus,
Riddle Peter N.,
Noble Mark
Publication year - 1991
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440040509
Subject(s) - progenitor cell , biology , platelet derived growth factor , progenitor , growth factor , oligodendrocyte , microbiology and biotechnology , platelet derived growth factor receptor , astrocyte , vimentin , immunology , stem cell , endocrinology , central nervous system , genetics , immunohistochemistry , receptor , myelin
We report that platelet‐derived growth factor (PDGF) is a potent mitogen for oligodendrocyte type‐2 astrocyte (O‐2A) progenitor cells derived from the optic nerves of adult rats. Moreover, O‐2A adult progenitors cultured in PDGF express the range of properties we have described previously for O‐2A adult progenitors cultured in the presence of type‐1 astrocytes. Similarly, previous studies have demonstrated that PDGF is able to mimic the influence of type‐1 astrocytes on O‐2A perinatal progenitors. Specifically, O‐2A adult progenitors and O‐2A perinatal progenitors exposed to PDGF express differences in average cell cycle time (59 ± 5 h for O‐2A adult progenitors versus 20 ± 6 h for O‐2A perinatal progenitors), average rate of migration (4.1 ± 0.6 μm h −1 versus 24.6 ± 5.4 μm h −1 ), morphology (unipolar versus bipolar), and antigenic phenotype (04 + vimentin − versus 04 − vimentin + ). Thus, our present results indicate that a single signalling molecule secreted by type‐1 astrocytes produces markedly different cellular behaviours in two related O‐2A progenitor populations.