Premium
Remyelination of demyelinated rat axons by transplanted mouse oligodendrocytes
Author(s) -
Crang A. J.,
Blakemore W. F.
Publication year - 1991
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440040308
Subject(s) - remyelination , biology , neuroglia , lesion , oligodendrocyte , transplantation , myelin , pathology , microbiology and biotechnology , central nervous system , anatomy , neuroscience , medicine
The injection of the gliotoxic agent ethidium bromide (EB) into spinal white matter produces a CNS lesion in which it is possible to investigate the ability of transplanted glial cells to reconstruct a glial environment around demyelinated axons. This study demonstrates that transplanted mouse glial cells can repopulate EB lesions in rats provided tissue rejection is controlled. In X‐irradiated EB lesions in cyclosporin‐A‐treated rats, mouse oligodendrocytes remyelinated rat axons and, together with mouse astrocytes, re‐established a CNS environment. When transplanted into nonirradiated EB lesions in nude rats, mouse glial cells modulated the normal host repair by Schwann cells to remyelination by oligodendrocytes. In both X‐irradiated and non‐irradiated EB lesions, transplanted mouse glial cells behaved similarly to isogenic rat glial cell transplants (Blackemore and Crang Dev Neurosci, 1988;10:1–10; J Neurocytol, 1989;18:519–528). These findings indicate that the cell‐cell interactions involved in reconstruction of a glial environment are common to both mouse and rat.