Premium
Tracing glial cell lineages in the mammalian forebrain
Author(s) -
Goldman James E.,
Vaysse Pierre J.J.
Publication year - 1991
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440040206
Subject(s) - gliogenesis , biology , lineage (genetic) , neuroscience , forebrain , progenitor cell , context (archaeology) , cell lineage , oligodendrocyte , neuroglia , cell type , central nervous system , cellular differentiation , stem cell , cell , microbiology and biotechnology , genetics , myelin , gene , paleontology
Astrocytes and oligodendrocytes emerge in late gestational and early post‐natal development in the mammalian CNS. The nature, and number, of progenitors for each glial type is a central question. This review will focus upon several unresolved issues relating to glial cell lineages and describe new methods to try to illuminate these issues further: (1) How can developmental patterns by which immature neuroectodermal cells give rise to classes of neurons and glia be understood in the context of lineage? (2) What are the lineage relationships among the various cell classes, how many glial lineages are there in the developing CNS, and how can recent methods of clonal analysis using stable markers be used to clarify lineage patterns? (3) Do patterns of gliogenesis vary in different regions of the CNS? (4) How do patterns of gliogenesis observed in vitro relate to those in vivo?.