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Astrocytes: A possible primary site for colchicine‐mediated neurotoxicity in the rat striatum
Author(s) -
Pitts Olin M.,
Cohen Martin R.,
McAmis William,
Gutman Robert L.
Publication year - 1991
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440040114
Subject(s) - colchicine , striatum , neurotoxicity , biology , ultrastructure , astrocyte , neuroscience , central nervous system , pathology , anatomy , medicine , toxicity , dopamine , genetics
Ultrastructural changes in rat astrocytes including endfoot swelling and rupture of plasma membranes were seen as early as 1 h after injection of 6.0 μg colchicine (CO) into the striatum. Significant change in neuronal morphology was not seen by 24 h. Astrocytes may therefore be primary targets for CO‐mediated damage, which then may have secondary neurotoxic consequences.