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Experimental inhibition of peroxisomal β‐oxidation in rats: Influence on brain myelination
Author(s) -
Van Den Branden Christiane,
Leeman Jan,
Dacremont Georges,
Collumbien Robert,
Roels Frank
Publication year - 1990
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440030604
Subject(s) - biology , neuroscience , peroxisome , biochemistry , receptor
Oral administration of thioridazine, an inhibitor of peroxisomal β‐oxidation, to normal rats from weaning till day 60 causes a small increase of the very long chain fatty acid C26 in brain lipids. Myelination in the brain is decreased. In the genu of the corpus callosum the ratio of non‐myelinated/myelinated axons is increased. In the commissura anterior the myelin sheaths of the axons are significantly thinner in treated than in control animals. Undernourishment caused by the drug is minimal in this experiment. Area and total DNA of glial nuclei are unaltered in both the genu and the commissura anterior of treated rats. The distribution of chromatin (texture), however, shows small differences in the corpus callosum.