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Brain astrocytes express region‐specific surface glycoproteins in culture
Author(s) -
Barbin Gilles,
Katz David M.,
Chamak Brigitte,
Glowinski Jacques,
Prochiantz Alain
Publication year - 1988
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440010111
Subject(s) - biology , astrocyte , glycoprotein , neuroscience , striatum , midbrain , lectin , cerebellum , neuroglia , morphogenesis , neuron , central nervous system , microbiology and biotechnology , biochemistry , gene , dopamine
Astrocytes derived from the mouse brain mesencephalon and striatum regulate neuronal morphogenesis in a region‐specific manner in vitro. To begin defining molecular mechanisms that may underlie this functional heterogeneity, lectin probes were used to compare surface glycoproteins expressed by astrocytes from different brain regions. These experiments demonstrated marked differences in surface glycoproteins depending on the anatomic origin of the astrocytes. In particular, mesencephalic and cerebellar astrocytes express a fucosylated glycoprotein with and apparent molecular weight of 190 kD that is absent or rarely expressed by striatal or cortical astrocytes. These findings raise the possibility that carbohydrate diversity of astrocyte surface molecules may play a role in the heterogeneity of region‐specific neuron‐glial interactions.