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Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus
Author(s) -
Tetzlaff W.,
Graeber M. B.,
Bisby M. A.,
Kreutzberg G. W.
Publication year - 1988
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.440010110
Subject(s) - axotomy , glial fibrillary acidic protein , biology , gfap stain , facial nerve , astrocyte , regeneration (biology) , neuroglia , anatomy , neuroscience , microbiology and biotechnology , central nervous system , immunohistochemistry , immunology
Glial fibrillary acidic protein (GFAP) increases in astrocytes following axotomy of facial motoneurons. In the present study we quantified GFAP synthesis both in regenerating facial nuclei after nerve crush and in nonregenerating facial nuclei after nerve resection. An increase in GFAP synthesis during regeneration occurs as early as 24 h after the axotomy. Thus, the increase in the astrocytic GFAP synthesis seems to be the earliest glial response to retrograde changes in facial motoneurons.