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IL ‐17 signaling induces iNOS + microglia activation in retinal vascular diseases
Author(s) -
Zhou Tian,
Liu Yan,
Yang Ziqi,
Ni Biyan,
Zhu Xiaowei,
Huang Zijing,
Xu Huiyi,
Feng Qiumin,
Lin Xiaojing,
He Chang,
Liu Xialin
Publication year - 2021
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.24063
Subject(s) - microglia , retinal , biology , microbiology and biotechnology , nitric oxide synthase , signal transduction , inflammation , nitric oxide , retina , leukostasis , neuroscience , immunology , biochemistry , endocrinology
Abstract Activation of microglia and inflammation‐mediated vascular damages are suggested to play a decisive role in the pathogenesis of various retinopathies. The inducible nitric oxide synthase (iNOS) was required for activated microglia‐mediated injuries. However, the induction mechanism of microglia activation during retinal vascular diseases is still elusive. Here we showed that IL‐17 induced microglia activation with high expression of iNOS and promoted the development of retinal vascular diseases. IL‐17‐dependent activation of the STAT3‐iNOS pathway was essentially required for microglia activation, which promoted endothelial cell growth and accelerated vascular leakage and leukostasis via IL‐6 in vitro and in vivo. Taken together, our data provide novel mechanistic insights on microglia activation‐mediated retinopathy, unveil the specific role of IL‐17 on microglia, and define novel therapeutic targets for treating retinal vascular diseases.