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How microbiota shape microglial phenotypes and epigenetics
Author(s) -
Erny Daniel,
Prinz Marco
Publication year - 2020
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.23822
Subject(s) - microglia , biology , innate immune system , neuroscience , crosstalk , immune system , homeostasis , central nervous system , phenotype , immunology , endogeny , inflammation , microbiology and biotechnology , genetics , gene , physics , endocrinology , optics
Among the myeloid cells in the central nervous system (CNS) microglia are the main representatives of the innate immune system. Microglial fulfil tasks beyond phagocytosing debris and host defense against invading microorganism. During brain development microglia guide for example neurons for proper CNS formation, in adulthood they maintain tissue homeostasis and in aging microglia may become pro‐inflammatory and finally exhausted. Recently, several endogenous and exogenous factors were identified that essentially shape the microglial phenotype during both steady‐state and pathological conditions. On the one hand, microglia receive inputs from CNS‐endogenous sources for example, via crosstalk with other glial cells and neurons but on the other hand microglia are also highly modulated by external signals. Among them, host microbiota—the host's resident bacteria—are vital regulators of the CNS innate immune system. This review summarizes key extrinsic and intrinsic factors, with special focus on the host microbiota, that essentially influence microglia functions and states during development, homeostasis, and disease.

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