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LncRNA BC088259 promotes Schwann cell migration through Vimentin following peripheral nerve injury
Author(s) -
Yao Chun,
Chen Yanping,
Wang Jing,
Qian Tianmei,
Feng Wei,
Chen Yuanyuan,
Mao Susu,
Yu Bin
Publication year - 2020
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.23749
Subject(s) - schwann cell , biology , peripheral nerve injury , sciatic nerve injury , vimentin , regeneration (biology) , neuroscience , downregulation and upregulation , sciatic nerve , nerve injury , gene silencing , cell , microbiology and biotechnology , immunology , anatomy , immunohistochemistry , gene , genetics
Schwann cell, the major glial cell in the peripheral nervous system, plays an essential role in peripheral nerve regeneration. However, the regulation of Schwann cell behavior following nerve injury is insufficiently explored. According to the development of high‐throughput techniques, long noncoding RNAs (lncRNAs) have been recognized. Accumulating evidence shows that lncRNAs take part in diverse biological processes and diseases. Here, by microarray analysis, we identified an upregulated lncRNA profile following sciatic nerve injury and focused on BC088259 for further investigation. Silencing or overexpression of BC088259 could affect Schwann cell migration. Mechanistically, BC088259 might exert this regulatory role by directly binding with Vimentin. Collectively, our study not only revealed a set of upregulated lncRNAs following nerve injury but also identified a new functional lncRNA, BC088259, which was important for Schwann cell migration, providing a therapeutic avenue toward peripheral nerve injury.