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Neuronal input triggers Ca 2+ influx through AMPA receptors and voltage‐gated Ca 2+ channels in oligodendrocytes
Author(s) -
Barron Tara,
Kim Jun Hee
Publication year - 2019
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.23670
Subject(s) - ampa receptor , glutamate receptor , biology , neuroscience , biophysics , depolarization , voltage dependent calcium channel , axon , stimulation , receptor , microbiology and biotechnology , calcium , biochemistry , chemistry , organic chemistry
Communication between neurons and developing oligodendrocytes (OLs) leading to OL Ca 2+ rise is critical for axon myelination and OL development. Here, we investigate signaling factors and sources of Ca 2+ rise in OLs in the mouse brainstem. Glutamate puff or axon fiber stimulation induces a Ca 2+ rise in pre‐myelinating OLs, which is primarily mediated by Ca 2+ ‐permeable AMPA receptors. During glutamate application, inward currents via AMPA receptors and elevated extracellular K + caused by increased neuronal activity collectively lead to OL depolarization, triggering Ca 2+ influx via P/Q‐ and L‐type voltage‐gated Ca 2+ (Ca v ) channels. Thus, glutamate is a key signaling factor in dynamic communication between neurons and OLs that triggers Ca 2+ transients via AMPARs and Ca v channels in developing OLs. The results provide a mechanism for OL Ca 2+ dynamics in response to neuronal input, which has implications for OL development and myelination.