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The conceptual introduction of the “demyelinating Schwann cell” in peripheral demyelinating neuropathies
Author(s) -
Park Hwan Tae,
Kim Jong Kuk,
Tricaud Nicolas
Publication year - 2019
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.23509
Subject(s) - schwann cell , wallerian degeneration , myelin , neuroscience , demyelinating disease , demyelinating disorder , biology , reprogramming , cell , microbiology and biotechnology , central nervous system , genetics
Myelinating Schwann cells undergo irreversible demyelination in many demyelinating neuropathies that show complete demyelination of the internode. Dedifferentiation, reprogramming, and myelin clearance processes—which are specifically discussed in this article—appear to be shared by various demyelinating peripheral conditions, such as Wallerian degeneration, immune‐mediated, and toxic demyelinating diseases. We propose to introduce the concept of the “demyelinating Schwann cell (DSC)” as a novel cell phenotype, which has specific properties required for myelin sheath clearance. We anticipate that the introduction of the DSC concept will provide a significant advance in understanding the pathophysiological mechanisms of demyelinating peripheral neuropathies.