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Oligodendrocyte generation during mouse development
Author(s) -
Takebayashi Hirohide,
Ikenaka Kazuhiro
Publication year - 2015
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.22863
Subject(s) - remyelination , neuroscience , biology , oligodendrocyte , myelin , olig2 , multiple sclerosis , central nervous system , morphogenesis , brain development , function (biology) , gene , immunology , microbiology and biotechnology , genetics
Oligodendrocytes (OLs) are glial cells, which generate myelin in the central nervous system. Their interesting developmental features attract many neurobiologists eager to study cell differentiation, gene expression regulation, or dynamic morphogenesis. Their primary role in protecting the axons has major impacts in the medical research field: in multiple sclerosis, a demyelinating disease in which remyelination is blocked. Oligodendrogenesis is involved in higher brain function including motor skill learning and cognitive function. Here, we review advances in the research on OL development and highlight areas where questions remain to be answered in both developmental biology and neurobiology related aspects. GLIA 2015;63:1350–1356