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Nitric oxide targets oligodendrocytes and promotes their morphological differentiation
Author(s) -
Garthwaite Giti,
HampdenSmith Kathryn,
Wilson Gary W.,
Goodwin David A.,
Garthwaite John
Publication year - 2015
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.22759
Subject(s) - oligodendrocyte , biology , brainstem , neuroscience , nitric oxide , cerebellum , neuroglia , microbiology and biotechnology , myelin , central nervous system , endocrinology
Main Points NO stimulated oligodendrocyte cGMP accumulation in cerebellar and brainstem slices, and in cortical cultures. In response, cultured oligodendrocytes underwent a morphological expansion, suggesting a role for NO/cGMP in activity‐dependent myelination.
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