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A proinvasive role for the Ca 2+ ‐activated K + channel KCa3.1 in malignant glioma
Author(s) -
Turner Kathryn L.,
Honasoge Avinash,
Robert Stephanie M.,
McFerrin Michael M.,
Sontheimer Harald
Publication year - 2014
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.22655
Subject(s) - gene knockdown , glioma , downregulation and upregulation , biology , cancer research , small hairpin rna , in vivo , in vitro , cell culture , gene , genetics
Main Points Using the NCI database, we found that upregulation of KCa3.1 correlates with poor prognosis in patients. Pharmacological inhibition or genetic knockdown of KCa3.1 decreases glioma migration, as investigated in vitro and in situ in multiple glioma cell types, including patient‐derived xenograft‐propagated tumors. Glioma invasion is also attenuated by shRNA knockdown of KCa3.1 in tumor cells implanted in mice in vivo .