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Classical and unconventional pathways of vesicular release in microglia
Author(s) -
Prada Ilaria,
Furlan Roberto,
Matteoli Michela,
Verderio Claudia
Publication year - 2013
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.22497
Subject(s) - microglia , neuroprotection , biology , secretion , neuroscience , immune system , inflammation , microbiology and biotechnology , microvesicles , cell type , extracellular , cell , immunology , gene , microrna , biochemistry
Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of extracellular membrane vesicles (EMVs) into the pericellular space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing damage to neurons or playing a supportive, neuroprotective role. In this review, we highlight the emerging concepts related to vesicular mechanisms of secretion operating in microglial cells, with the aim of dissecting how microglia communicate with other cell types within the brain microenvironment in health and disease.