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Microglia and intractable chronic pain
Author(s) -
Tsuda Makoto,
Beggs Simon,
Salter Michael W.,
Inoue Kazuhide
Publication year - 2013
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.22379
Subject(s) - purinergic receptor , neuroscience , microglia , neuropathic pain , chronic pain , central nervous system , biology , pathological , purinergic signalling , receptor , medicine , pathology , inflammation , immunology , adenosine receptor , biochemistry , agonist
Many pathological processes within the central nervous system are mediated by complex interactions between neurons and resident glial cells. In the case of painful peripheral neuropathy, spinal microglia react and undergo a series of changes that directly influence the establishment of neuropathic pain states. Purinergic signaling has been shown to be at the center of this reactivity, and here we review recent mechanistic advances describing the importance of microglial P2 receptors and their interactions with neuronal populations in the development of neuropathic pain. © Wiley Periodicals, Inc.