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In vitro modeling of central nervous system myelination and remyelination
Author(s) -
Jarjour Andrew A.,
Zhang Hui,
Bauer Nina,
ffrenchConstant Charles,
Williams Anna
Publication year - 2012
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.21231
Subject(s) - remyelination , neuroscience , context (archaeology) , biology , central nervous system , strengths and weaknesses , cognitive science , psychology , myelin , paleontology , social psychology
This review aims to summarize the current techniques to study myelination and remyelination in culture systems. We attempt to put these into historical context, and to identify the strengths and weaknesses of each approach, which vary depending on the experimental question to be tested. We discuss the difficulty and importance of quantification of myelination and in particular remyelination. Finally, we provide our predictions of how these techniques will and should develop in the future. © 2011 Wiley Periodicals, Inc.