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Cell‐context specific role of the E2F/Rb pathway in development and disease
Author(s) -
Swiss Victoria A.,
Casaccia Patrizia
Publication year - 2010
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20933
Subject(s) - biology , e2f , context (archaeology) , neuroscience , cell cycle , central nervous system , disease , cell type , cell , genetics , pathology , medicine , paleontology
Development of the central nervous system (CNS) requires the generation of neuronal and glial cell subtypes in appropriate numbers, and this demands the careful coordination of cell‐cycle exit, survival, and differentiation. The E2F/Rb pathway is critical for cell‐cycle regulation and also modulates survival and differentiation of distinct cell types in the developing and adult CNS. In this review, we first present the specific temporal patterns of expression of the E2F and Rb family members during CNS development and then discuss the genetic ablation of single or multiple members of these two families. Overall, the available data suggest a time‐dependent and cell‐context specific role of E2F and Rb family members in the developing and adult CNS. © 2009 Wiley‐Liss, Inc.