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Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation
Author(s) -
Birchmeier Carmen,
Nave KlausArmin
Publication year - 2008
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20753
Subject(s) - neuregulin , neuroscience , biology , schwann cell , neuregulin 1 , axon , myelin , neuroglia , nervous system , central nervous system , microbiology and biotechnology , signal transduction
Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed “neuregulin”, promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding. © 2008 Wiley‐Liss, Inc.