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Molecular domains of myelinated axons in the peripheral nervous system
Author(s) -
Salzer James L.,
Brophy Peter J.,
Peles Elior
Publication year - 2008
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20750
Subject(s) - biology , node of ranvier , neuroscience , axon , peripheral nervous system , nervous system , action potential , myelin sheath , schwann cell , anatomy , central nervous system , myelin , electrophysiology
Myelinated axons are organized into a series of specialized domains with distinct molecular compositions and functions. These domains, which include the node of Ranvier, the flanking paranodal junctions, the juxtaparanodes, and the internode, form as the result of interactions with myelinating Schwann cells. This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon. © 2008 Wiley‐Liss, Inc.