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Regulation of Schwann cell function by the extracellular matrix
Author(s) -
Chernousov Michael A.,
Yu WeiMing,
Chen ZuLin,
Carey David J.,
Strickland Sidney
Publication year - 2008
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20740
Subject(s) - schwann cell , extracellular matrix , laminin , biology , microbiology and biotechnology , neuroscience , neurite , cell adhesion , peripheral nervous system , dystroglycan , cell , central nervous system , in vitro , genetics
Abstract Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development. © 2008 Wiley‐Liss, Inc.