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Transcriptional control of oligodendrogenesis
Author(s) -
Nicolay Danette J.,
Doucette J. Ronald,
Nazarali Adil J.
Publication year - 2007
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20540
Subject(s) - biology , sonic hedgehog , neuroscience , transcription factor , bone morphogenetic protein , myelin , notch signaling pathway , hedgehog , bone morphogenetic protein 4 , signal transduction , central nervous system , microbiology and biotechnology , genetics , gene
Oligodendrocytes (OGs) assemble the myelin sheath around axons in the central nervous system. Specification of cells into the OG lineage is largely the result of interplay between bone morphogenetic protein, sonic hedgehog and Notch signaling pathways, which regulate expression of transcription factors (TFs) dictating spatial and temporal aspects of oligodendrogenesis. Many of these TFs and others then direct OG development through to a mature myelinating OG. Here we describe signaling pathways and TFs that are inductive, inhibitory, and/or permissive to OG specification and maturation. We develop a basic transcriptional network and identify similarities and differences between regulation of oligodendrogenesis in the spinal cord and brain. © 2007 Wiley‐Liss, Inc.