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Transcription factor co‐expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord
Author(s) -
Kitada Masaaki,
Rowitch David H.
Publication year - 2006
Publication title -
glia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.954
H-Index - 164
eISSN - 1098-1136
pISSN - 0894-1491
DOI - 10.1002/glia.20354
Subject(s) - olig2 , biology , oligodendrocyte , white matter , sox10 , transcription factor , spinal cord , central nervous system , grey matter , myelin , neuroscience , microbiology and biotechnology , genetics , gene , medicine , radiology , magnetic resonance imaging
Oligodendrocytes and their precursors serve critical roles in the maintenance of neurological function. Although activity of the transcription factors (TFs) Olig1, Olig2, Sox10, and Nkx2.2 is required during early oligodendrocyte development, their later expression in adult central nervous system is rather poorly characterized. Here we have analyzed co‐expression patterns of these transcriptional proteins in the mouse cervical spinal cord. Our findings indicate that TF co‐expression patterns describe heterogeneity in adult oligodendroglial populations (1) in distinct sub‐regions of grey and white matter and (2) with respect to level of maturation from proliferating precursors to myelinating oligodendrocytes. Our findings suggest that TF co‐expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia. © 2006 Wiley‐Liss, Inc.